Hubbs Lab

Translational Neuroscience Center
Boston Children's Hospital · Harvard Medical School
We accelerate the discovery of treatments for neurodevelopmental disorders.
Led by Jed L. Hubbs, PhD, Assistant Professor of Neurology, Harvard Medical School
Research Highlights
From patient-derived neurons to preclinical candidates for rare neurodevelopmental disorders.
Therapeutics for Neurodevelopmental Disorders
Phenotypic screening in patient-derived iPSC neurons to find compounds that rescue disease phenotypes.
iPSC Neurons Phenotypic Screening
Medicinal Chemistry of Natural Product Leads
CBD analog development for non-opioid pain and epilepsy, modulating multiple ion channels involved in pain and seizure signaling with improved drug-like properties.
Medicinal Chemistry Natural Products
RNA-Targeting Therapeutics
Antisense oligonucleotides, small molecules that target RNA splicing, and small molecule-RNA chimeras to upregulate gene expression for haploinsufficiency disorders.
ASOs Splicing Modulators RNA Chimeras
Drug Discovery Tools
Open-access computational tools built by the lab.
Drug Repurposing
AI-powered triage of a 10,794-compound library of FDA-approved drugs and tool compounds against any gene target, with relevance scoring and mechanistic rationale.
Drug Design
Multi-parameter optimization dashboard with ADMET profiling, on-target activity models, SHAP attribution, and interactive molecular editing.
Virtual Screening
Pick any target and see whatever the pipeline produced: a machine-learning potency ranking of an 8.4 million in-stock compound library, structure-based docked hits with the pose in 3D, and the consensus — compounds that came through both stages.
Target ID
Draw a compound and identify its most likely protein targets by reverse screening across thousands of human targets, with supporting evidence and a confidence-calibrated shortlist.
Quick Links
Explore the lab.
Preclinical Pipeline 15 programs from cohort to preclinical development Publications Selected papers from the lab