Hubbs Lab

Translational Neuroscience Center
Boston Children's Hospital · Harvard Medical School
We accelerate the discovery of treatments for severe pediatric neurological conditions.
Led by Jed L. Hubbs, PhD, Assistant Professor of Neurology, Harvard Medical School
Research Highlights
From patient-derived neurons to preclinical candidates for rare neurodevelopmental disorders.
Therapeutics for Neurodevelopmental Disorders
Phenotypic screening in patient-derived iPSC neurons to find compounds that rescue disease phenotypes.
iPSC Neurons Phenotypic Screening
Medicinal Chemistry of Natural Product Leads
CBD analog development for non-opioid pain and epilepsy, modulating multiple ion channels involved in pain and seizure signaling with improved drug-like properties.
Medicinal Chemistry Natural Products
RNA-Targeting Therapeutics
Antisense oligonucleotides, small molecules that target RNA splicing, and small molecule-RNA chimeras to upregulate gene expression for haploinsufficiency disorders.
ASOs Splicing Modulators RNA Chimeras
Drug Discovery Tools
Open-access computational tools built by the lab.
Drug Repurposing
AI-powered triage of a 2,975-compound library of FDA-approved drugs and tool compounds against any gene target, with relevance scoring and mechanistic rationale.
Claude Sonnet Tool Compounds
Drug Design
Multi-parameter optimization dashboard with ADMET profiling, on-target activity models, SHAP attribution, and interactive molecular editing.
ADMET-AI MPO SHAP
ASO Discovery
Antisense oligonucleotide design pipeline with splice-site targeting, off-target filtering, and thermodynamic scoring.
ASOs Splice Modulation
Quick Links
Explore the lab.
Preclinical Pipeline 15 programs from cohort to preclinical development Publications Selected papers from the lab Join Us Open positions for postdocs and research scientists