Publications & Patents

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration

Substituted phenols as ion channel binders Patent Pending

Tetrahydroimidazopyridine-benzothiazole compounds as ATG9A modulators for neurological diseases Patent Pending

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia

ALDH5A1-deficient iPSC-derived excitatory and inhibitory neurons display cell type specific alterations

GABA_A positive allosteric modulator crystalline salts (p-toluenesulfonic acid) Patent

GABA_A positive allosteric modulator compounds for treatment of itch and/or dermatitis Patent

GABA_A positive allosteric modulator crystalline salts (phosphoric acid) Patent

Treatment of epileptic conditions with GABA_A receptor modulators Patent Pending

Use of GABA_A receptor modulators for the treatment of pain Patent Pending

Histone deacetylase inhibitors Patent

Histone deacetylase inhibitors Patent

GABA_A positive allosteric modulator compounds, methods of making, and uses thereof Patent Pending

N-substituted 4-aminoquinazoline derivatives and methods of use Patent

HDAC inhibitors Patent

Histone deacetylase inhibitors Patent

Histone deacetylase inhibitors Patent

Itch suppression in mice and dogs by modulation of spinal α2 and α3 GABA_A receptors

Imidazoyl anilide derivatives and methods of use Patent

Histone deacetylase inhibitors Patent

HDAC inhibitors Patent

Minimization of drug-drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators

Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Modulation of gamma-secretase for the treatment of Alzheimer's disease

Optimization of a natural product-based class of gamma-secretase modulators

Initial optimization of a new series of gamma-secretase modulators derived from a triterpene glycoside

Purine derivatives as potent gamma-secretase modulators

Benzothiophene derivatives Patent

Benzothiophene hydroxamic acid derivatives Patent

Amino acid derivatives as histone deacetylase inhibitors

Multigram synthesis of the C29-C51 subunit and completion of the total synthesis of altohyrtin C (spongistatin 2)

A second-generation synthesis of the C1-C28 portion of the altohyrtins (spongistatins)

Ni(II) bis(oxazoline)-catalyzed enantioselective syn aldol reactions of N-propionylthiazolidinethiones in the presence of silyl triflates

Total synthesis of (±)-isoschizogamine