Colored circles are pathway nodes, sized by the number of disorders converging on them. Grey dots are disorders. Click either. Circle color is the pathway category. Line color and line end give the direction of effect: increased is a solid arrowhead, decreased is a dashed line ending in a bar, and variant-dependent is a dotted line ending in an open circle.
Fifteen nodes ranked by directional concordance, CNS druggability, and whether anything has shown clinical benefit. The conclusion column is an independent attempt to refute each one. Click a row to open it on the map.
Node-level agents could in principle serve several disorders; gene-specific agents cannot. Failures are retained deliberately.