TNC Preclinical Pipeline

Tracking progress from patient cohort to preclinical development in the Rosamund Stone Zander and Hansjoerg Wyss Translational Neuroscience Center.
Program Cohort iPSCs Phenotype Assay Screen Hit Lead Opt. Preclinical
CDKL5
PTEN
EHMT1 (Kleefstra)
FOXG1
Chr21 / Down Syndrome
ANKRD17 (CAGS)
SHANK3 (Phelan-McDermid)
SETBP1
KCNQ2
TSC2
SCN1A (Dravet)*
Epilepsy & Pain (CBD)*
AP-4 HSP*
SSADH
SynGAP1
Complete    In Progress    * Patent application filed