Postdoctoral Fellow
Hubbs Lab · Translational Neuroscience Center · Boston Children's Hospital
A Postdoctoral Fellow position with a flexible start date is available in the research lab of
Dr. Jed Hubbs at Boston Children's Hospital. We are seeking an independent, entrepreneurial,
and self-motivated scientist to join our team to drive drug discovery projects for rare
neurodevelopmental disorders. This role is ideal for a researcher who thrives at the interface
of chemistry and biology, using human induced pluripotent stem cell (iPSC)-derived neurons to
screen for and validate novel therapeutics. The fellow will work in a highly multidisciplinary
environment, collaborating closely with the Medicinal Chemistry Core and the
Human Neuron Core to translate basic science into clinical candidates.
The mission of the Hubbs Lab is to accelerate the discovery of treatments for severe pediatric
neurological conditions by combining the rigor of academic research with the operational
efficiency of a biotech startup. Situated within the world-class Harvard ecosystem, our lab
operates with a translational focus, utilizing cutting-edge technology to identify small molecule
interventions. The successful candidate will join a fast-paced team and will be expected to not
only execute bench science but also function as a project leader, managing external resources
and collaborating with diverse experts.
Duties & Responsibilities
- Differentiation of human iPSCs into neuronal subtypes and execution of phenotypic screening assays.
- Leading drug discovery campaigns, including assay development, high-content imaging, and data analysis.
- Independently leading scientific projects.
- Preparing manuscripts and drafting grant applications.
- Managing external research operations, including designing and overseeing studies conducted at Contract Research Organizations (CROs).
- Collaborating with medicinal chemists to interpret SAR (structure-activity relationships) and guide compound optimization.
- Mentoring junior staff and maintaining a high standard of data integrity and organization.
- Presenting results to internal collaborators and external researchers.
Qualifications
- A PhD degree in Neuroscience, Cell Biology, Chemical Biology, or a related field with 0-4 years of relevant experience.
- Experience with iPSC tissue culture and neuronal differentiation is required; experience with organoids preferred.
- A strong interest in drug discovery, intellectual property, and translational science.
- An interest in applying computational and/or AI tools to research.
- Experience with organic chemistry, chemical biology, and/or small molecule screening is preferred.
- Demonstrated ability to work independently and manage multiple complex workflows.
- Excellent communication skills and the ability to thrive in a collaborative, team-oriented environment.
To apply: [email protected]